Treatment of Factor VIII Inhibitor Patients
نویسندگان
چکیده
منابع مشابه
FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY
Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...
متن کاملfactor v and viii inhibitor in patients with combined factor v and viii deficiency
patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). in this survey we detected factor v and viii inhibitor in ten patients with combined deficiency of factors v and viii from north east of iran (khorassan province). it was revealed in our survey that eight patients had both factor v and factor viii inhib...
متن کاملAcquired factor VIII inhibitor.
PERSISTENT or uncontrolled bleeding is one of the most feared consequences of any surgical procedure. Numerous factors can contribute to its etiology. Among these, both inherited and acquired disorders of coagulation and/or thrombocyte function need to be taken into account. Acquired hemophilia can be caused by antibodies to coagulation factors. Antibodies can arise in hemophilic or nonhemophil...
متن کاملThe evidence behind inhibitor treatment with porcine factor VIII.
Factor VIII auto- and alloantibodies neutralise porcine factor VIII to a lesser extent than factor VIII of human origin. The reduced reactivity of the porcine molecule, predominantly due to sequence variation in the A2 and C2 domains, has been the rationale for using porcine factor VIII to secure haemostasis for patients with factor VIII inhibitors. Porcine factor VIII has been shown to provide...
متن کاملImmunoblot analysis shows changes in factor VIII inhibitor chain specificity in factor VIII inhibitor patients over time.
We have used immunoblotting of purified factor VIII (FVIII) to determine whether or not changes in FVIII chain specificity occur during the course of an inhibitor. Serial plasma samples from 15 inhibitor patients (13 hemophilic and two spontaneous) were analyzed. Nine of the 15 antibodies, all with epitopes on the 44-kilodalton (Kd) thrombin fragment of the 92-Kd FVIII heavy chain and/or the 72...
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ژورنال
عنوان ژورنال: Pathophysiology of Haemostasis and Thrombosis
سال: 1981
ISSN: 1424-8832,1424-8840
DOI: 10.1159/000214544